Preparation of lauryllactam through cyclododecane...

C - Chemistry – Metallurgy – 07 – D

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C07D 225/02 (2006.01) C07D 201/04 (2006.01)

Patent

CA 2282871

Le lauryllactame est préparé en faisant réagir photochimiquement le cyclododécane solubilisé dans un solvant organique, un agent nitrosant et du chlorure d'hydrogène en présence d'acide méthanesulfonique pour former l'oxime de la cyclododécanone, et en soumettant l'oxime à une transposition de Beckmann en présence d'acide méthanesulfonique. L'utilisation de l'acide méthanesulfonique permet de pallier aux inconvénients reliés à l'utilisation conventionelle de l'acide sulfurique dans les étapes de photonitrosation et de transposition de Beckmann.

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