Preparation of lignan analogues

Details Preparation of lignan analogues Preparation of lignan analogues

C - Chemistry, Metallurgy

07

C

C07C 69/94 (2006.01) A61K 31/12 (2006.01) A61K 31/235 (2006.01) A61K 31/335 (2006.01) A61K 31/36 (2006.01) C07C 39/12 (2006.01) C07C 59/76 (2006.01) C07C 67/24 (2006.01) C07C 67/347 (2006.01) C07C 69/738 (2006.01) C07D 307/86 (2006.01) C07D 307/88 (2006.01) C07D 317/70 (2006.01) C07D 493/04 (2006.01)

Patent

CA 2121060

This invention relates to a process for preparing the compounds of lignan series in a selective manner in terms of the positions, and to intermediates thereof. This invention provides a process for preparing compounds of the formula (I): (See formula I) which is characterized by that a lactone compound of the formula (II): (See formula II) is reacted with an unsaturated ketone represented by the formula (III): (See formula III) and the resulting compound is subjected to dehydration in which, R1 is alkyl, cycloalkyl, cycloalkyl (lower alkyl), or aralkyl; R2 and R3 each is lower alkyl or R2 and R3 are combined together to form an alkylenedioxy; R4 is lower alkoxy or hydrogen; R5 and R6 each is lower alkyl; and R7 is lower alkyl. The invention also provides the compounds of the formulas (II) and (III).

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