Preparation of microparticles having improved flowability

Details Preparation of microparticles having improved flowability Preparation of microparticles having improved flowability

B - Operations, Transporting

01

J

B01J 13/12 (2006.01) A61K 9/16 (2006.01) B01F 17/00 (2006.01) B01J 13/20 (2006.01)

Patent

CA 2432279

Methods for preparing microparticles having improved flowability to facilitate processing in automated equipment. Microparticles are conditioned so that a flowability index of the microparticles is greater than about 60. The conditioning preferably includes maintaining the microparticles at a conditioning temperature for a period of time. The conditioning can be used with microparticles containing an active agent, and with placebo microparticles, and it is reversible.

L'invention concerne des méthodes de préparation de microparticules présentant une aptitude améliorée à l'écoulement, en vue de faciliter leur traitement dans des équipements automatiques. Ces microparticules sont traitées pour que leur indice d'aptitude à l'écoulement soit supérieur à environ 60. De préférence, ce traitement consiste à maintenir les microparticules à une température de traitement pendant un certain temps. Ce traitement, qui est réversible, peut être appliqué à des microparticules contenant un agent actif, ainsi qu'à des microparticules placebo.

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