Preparation of n-(1-alkoxyalkyl) formamide and alkylidene...

C - Chemistry – Metallurgy – 07 – C

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C07C 231/12 (2006.01) C07C 231/08 (2006.01) C07C 233/18 (2006.01) C07C 233/36 (2006.01)

Patent

CA 2063160

PATENT 186PUS04413 ABSTRACT This invention relates to an improved process for the formation of N-(l-alkoxyalkyl)amides with coproduction of alkylidene bisamides. The N-(l-alkoxyalkyl)formamides of this invention are prepared by reacting formamide with an acetal or hemiacetal carboxylate ester represented by the formulas below in the presence of a solid acid ion exchange resin wherein the acid groups have been neutralized with an amine compound having a pKa (as the protonated amine in water) from about 4 to 9. The hemiacetal ester is represented by formula I and the acetal is represented by formula II. I II Image Image In the above formulas R is C1-C8 alkyl aralkyl or aryl; R1 and R2 are C1-C8 alkyl or aryl; and R3 is secondary or tertiary alkyl having from 3-8 carbon atoms.

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