Preparation of n-acyl-aminomethylphosphonates

Details Preparation of n-acyl-aminomethylphosphonates Preparation of n-acyl-aminomethylphosphonates

C - Chemistry, Metallurgy

07

F

260/501.1

C07F 9/38 (2006.01)

Patent

CA 2003852

PREPARATION OF N-ACYL-AMINOMETHYLPHOSPHONATES N-Acyl-aminomethylphosphonic acids represented by the formula Image wherein R is selected from the group consisting of methyl and aryl are prepared by: (a) bringing together under substantially anhydrous reaction conditions an amide represented by the formula Image wherein R is as defined above and paraformaldehyde; and thereafter, (b) adding phosphorous trihalide to the reaction mixture.

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