Preparation of n-methyl-3-hydroxy- 3-(2-thienyl)propylamine...

Details Preparation of n-methyl-3-hydroxy- 3-(2-thienyl)propylamine... Preparation of n-methyl-3-hydroxy- 3-(2-thienyl)propylamine...

C - Chemistry, Metallurgy

07

D

C07D 333/20 (2006.01) C07D 333/22 (2006.01)

Patent

CA 2477082

A novel route is described for the synthesis of N-methyl-3-hydroxy-3-(2- thienyl)propylamine IV, which can be used as a starting compound for the preparation of duloxetine. N-methyl-3-hydroxy-3-(2-thienyl)propylamine is synthesized via novel thiophene derivatives containing carbamate groups, I and IIa, as intermediates.

La présente invention a trait à une nouvelle voie pour la synthèse de N-méthyl-3-hydroxy-3-(2-thiényl)propylamine IV, qui peut être utilisée en tant que composé de départ pour la préparation de duloxetine. On effectue la synthèse de N-méthyl-3-hydroxy-3-(2-thiényl)propylamine via de nouveaux dérivés de thiophène contentant des groupes carbamates, I et IIA, en tant qu'intermédiaires.

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