Preparation of n2-alkylated 1,2,3-triazoles

Details Preparation of n2-alkylated 1,2,3-triazoles Preparation of n2-alkylated 1,2,3-triazoles

C - Chemistry, Metallurgy

07

D

C07D 413/10 (2006.01)

Patent

CA 2529109

Methods and materials for preparing N2-alkylated triazoles, such as 3-{4-[3~(5- methyl-2-phenyl-oxazol-4-yl)-propyl]-phenyl}-2- [1,2,3]triazol-2-yl-propionic acid, are disclosed. Such compounds are PPAR agonists that are useful for treating non~ insulin dependent diabetes.

L'invention concerne des méthodes et des matériaux utilisés pour préparer des triazoles N2-alkylés, tels que l'acide 3-{4-[3-(5-méthyl-2-phényl-oxazol-4-yl)-propyl]-phényl}-2- [1,2,3]triazol-2-yl-propionique. Ces composés représentent des agonistes des récepteurs activés proliférateurs du peroxysome (PPAR) utiles pour traiter le diabète non dépendant de l'insuline.

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