Preparation of native oncornavirus envelope subunits and...

C - Chemistry – Metallurgy – 12 – N

Patent

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167/130, 530/15.

C12N 7/06 (2006.01) C07K 14/15 (2006.01) A61K 39/00 (2006.01)

Patent

CA 1156647

ABSTRACT OF THE DISCLOSURE Non-denatured [gp90] is isolated from oncornavirus envelopes including feline and murine leukemia virus envelopes and utilized as vaccines by forming disulfide bonds between sub-units [gp70] and [pl5E], disrupting the viral envelope and separating gp90 from the other components of the lysed mixture. The materials as isolated may be used directly or in various compositions.

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