Preparation of nitratoalkyl-substituted cyclic ethers

C - Chemistry – Metallurgy – 07 – D

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260/368, 260/369

C07D 303/36 (2006.01) C07D 303/16 (2006.01) C07D 305/06 (2006.01)

Patent

CA 1328110

Abstract Preparation of Nitratoalkyl-substituted cyclic ethers A continuous process for producing nitratoalkyl-substituted cyclic ethers which consists of (a) cocurrently mixing a stream of N2O5 and a stream of an hydroxyalkyl-substituted cyclic ether each dissolved in an inert organic solvent, followed by (b) rapidly separating the nitric acid and nitratoalkyl coproducts before they can react together to rupture the ether ring. Step (b) is conveniently performed by quenching the product stream within approximately 15 seconds of its formation, in a basic aqueous solution into which the nitric acid is transferred from the organic phase and is neutralised. Examples of products which may be prepared by this process are nitratoalkyl-substituted oxiranes and oxetanes.

606325

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