Preparation of ó-arylalkanoic acids

Details Preparation of ó-arylalkanoic acids Preparation of ó-arylalkanoic acids

C - Chemistry, Metallurgy

07

C

260/351, 260/645

C07C 43/315 (2006.01) C07C 309/63 (2006.01) C07D 317/22 (2006.01)

Patent

CA 1338433

Pharmaceutically useful optically active .alpha.-arylalkanoic acids or esters, ortho esters, or amides thereof are stereoselectively prepared by contacting an aryl magnesium Grignard reagent with an optically active .alpha.-substituted acyl halide to form the optically active aryl .alpha.-substituted alkyl ketone, which is ketalized and rearranged to the desired optically active .alpha.-arylalkanoic acid or the corresponding ester, ortho ester or amide. In an alternate embodiment, the aryl .alpha.-substituted alkyl ketone is reduced to the corresponding alkanol, which is rearranged to the .alpha.-arylalkanal. The alkanal so produced is converted to the desired optically active .alpha.-arylalkanoic acid by conventional methods.

616341

Affiliated with

Also associated with

Rating

Preparation of ó-arylalkanoic acids does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Preparation of ó-arylalkanoic acids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation of ó-arylalkanoic acids will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1205783