Preparation of omeprazole and lansoprazole and intermediates...

Details Preparation of omeprazole and lansoprazole and intermediates... Preparation of omeprazole and lansoprazole and intermediates...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01)

Patent

CA 2170250

Omeprazole and lansoprazole, which are chemically pyridine-benzimidazole sulfinyl compounds, are produced from the corresponding acetamide-sulfide compounds by a process of oxidation to form the amide sulfinyl compound, followed by alkaline hydrolysis to the sulfinyl carboxylate or salt, and decarboxylation.

La présente invention concerne l'oméprazole et le lanzoprazole qui sont chimiquement des composés de pyridine-benzimidazole sulfinyle. Ils sont préparés par oxydation des composés acétamide-sulfide donnant ainsi le composé amide sulfinyle, puis par hydrolyse alcaline, donnant ainsi le sulfinyle carboxylate ou son sel, et enfin par décarboxylation.

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