Preparation of optically active norbornyl amine derivatives

Details Preparation of optically active norbornyl amine derivatives Preparation of optically active norbornyl amine derivatives

C - Chemistry, Metallurgy

07

C

260/605.3, 260/3

C07C 209/88 (2006.01) C07C 211/40 (2006.01) C07C 211/41 (2006.01) C07C 227/34 (2006.01) C07C 311/20 (2006.01) C07D 493/08 (2006.01)

Patent

CA 2039401

The present invention is directed to a process for preparing an optically active compound useful as an intermediate for the preparation of clinically important thromkbxane A2 (TXA2) receptor antagonist by resolving a racemic mixture of norbornyl amine of formula (I): (see formula I) wherin R1 is hydrogen, lower alkyl or lower alkyl substituted with -COOR3 at the terminal methyl residue; R3 is lower alkyl; Y is oxygen or methylene; m and n are independently 0 or 1 with a chiral acid.

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