C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 279/24 (2006.01) C07C 277/08 (2006.01) C07C 279/12 (2006.01) C07C 279/14 (2006.01) C07K 5/033 (2006.01)
Patent
CA 2183917
A process for preparing optically active (S)-(-) and (R)-(+)- deoxyspergualin and salts thereof of the formula I Image by reacting a compound of formula II Image with a compound of formula III Image in the presence of a condensing/dehydrating agent and an organic or inorganic base in an organic solvent to form a compound of formula IV Image which can then be converted to the desired final product of formula I via deprotection and hydrogenolysis. The invention also comprises the compounds of the formula II, IV and VII Image
Thottathil John K.
Wang Xuebao
Osler Hoskin & Harcourt Llp
Thottathil John K.
Wang Xuebao
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