Preparation of ortho-aminobenzotrifluoride

Details Preparation of ortho-aminobenzotrifluoride Preparation of ortho-aminobenzotrifluoride

C - Chemistry, Metallurgy

07

C

260/601

C07C 205/12 (2006.01) C07C 17/12 (2006.01)

Patent

CA 1215392

09-21-2110A PREPARATION OF ORTHO-AMINOBENZOTRIFLUORIDE ABSTRACT This invention relates to a process for the preparation of ortho- aminobenzotrifluoride (OABT) from benzotrifluoride (BTF). The process provides an overall route employing non-isolation of intermediates which can be run smoothly and which results in the preparation of OABT in high yields with less contamination. This process includes a catalytic halogenation step in which BTF is converted to meta-halo BTF and other mono and di-halo isomers of BTF followed by nitration in the same reaction vessel under conditions which do not favor nitration of the di-halo isomers of BTF to produce a mixture which predominates in 5-halo-2-nitro BTF. In the final step the 5-halo-2-nitro BTF present is reduced and hydrodehalogenated with H2 in the presence of a cata- lyst to form OABT. Recyclable BTF is also obtained from the final reaction.

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