Preparation of oxophthalazinyl acetic acids having...

C - Chemistry – Metallurgy – 07 – D

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260/351.1, 260/3

C07D 237/32 (2006.01) C07D 307/89 (2006.01) C07D 417/06 (2006.01) C07D 491/056 (2006.01)

Patent

CA 1321791

ABSTRACT OF THE DISCLOSURE Disclosed is a process for the preparation of oxophthalazinyl acetic acids of the formula: Image VIII wherein R1 is H or alkyl; R3 and R4 are H or substituent such as halo, alkyl, alkoxy, nitro or alkylthio; R5 and R6 are H or substituent; Z is H or CH3; and U is S, CH2 or a bond). The process comprises reacting an oxophthalazinyl acetic acid ester of the formula: Image VI (wherein W' is S, CH2 or a bond and Q is CN or Image where R2 is alkyl) with an aniline derivative of the formula: Image VII Also disclosed are processes for the preparation of such oxophthalazinyl esters.

568775

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