Preparation of oxymorphone, oxycodone and derivatives

Details Preparation of oxymorphone, oxycodone and derivatives Preparation of oxymorphone, oxycodone and derivatives

C - Chemistry, Metallurgy

07

D

C07D 489/02 (2006.01) A61K 31/485 (2006.01) C07D 489/08 (2006.01)

Patent

CA 2296035

The invention provides processes for the conversion of normorphinone and its derivatives, which can be synthesized from morphine, to the corresponding 14-hydroxynormorphinone and its derivatives including oxycodone, oxymorphone, noroxymorphone and naltrexone. Noroxymorphone is a key intermediate for the production of important narcotic analgesics and antagonists. The invention also provides certain novel intermediates.

Cette invention se rapporte à la conversion de nomorphinone et de ses dérivés, qui peuvent être synthétisées à partir de morphine, en 14-hydroxynomorphinone et dérivés correspondants, et notamment en oxycodone, oxymorphone, noroxymorphone et naltrexone. La noroxymorphone est un intermédiaire clé pour la production d'importants analgésiques morphiniques et antagonistes des morphiniques. Cette invention se rapporte en outre à certains nouveaux intermédiaires.

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