Preparation of pharmaceutical compositions

Details Preparation of pharmaceutical compositions Preparation of pharmaceutical compositions

A - Human Necessities

61

K

A61K 9/107 (2006.01) A61K 9/127 (2006.01) A61K 9/14 (2006.01) A61K 9/48 (2006.01) A61K 31/122 (2006.01) A61K 31/7088 (2006.01) A61K 38/13 (2006.01) A61K 47/24 (2006.01)

Patent

CA 2294337

A substantially homogenous composition for human administration comprises a biologically active lipophilic compound dissolved in or associated with at least one micelle-forming lipid. For example, cyclosporin A is dissolved or dispersed in the mixture of PC and MAPC. The composition may be made by dissolving the lipid material in ethanol, adding the lipophilic compound to the ethanol and removing the ethanol, after which the composition may be formulated for human oral administration.

La présente invention concerne une composition sensiblement homogène à administrer à un être humain, qui comprend un composé lipophyle biologiquement actif dissous ou associé à au moins un lipide formant des micelles. On dissout ou on disperse, par exemple, une cyclosporine A dans le mélange de phosphatidyle choline (PC) et de phosphatidyle choline mono acyle (MAPC). On réalise la composition en dissolvant le lipide dans de l'éthanol, en ajoutant le composé lipophile à l'éthanol et en éliminant l'éthanol, puis on formule la composition pour administration orale à un être humain.

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