Preparation of pharmaceutical salts of [1, 4] - bipiperidine

Details Preparation of pharmaceutical salts of [1, 4] - bipiperidine Preparation of pharmaceutical salts of [1, 4] - bipiperidine

A - Human Necessities

61

K

A61K 31/445 (2006.01) A61K 31/4745 (2006.01) A61P 11/06 (2006.01) A61P 37/00 (2006.01) C07D 401/04 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2544845

The invention provides anhydrous and hydrated forms of sodium salt of N-[ [4- (3, 4-dichlorophenoxy) [1, 4'-bipiperidin] -1'-yl]carbonyl]-4-methyl - benzenesulfonamide and crystalline forms of N- [[4-(3,4-dichlorophenoxy) [1,4' -bipiperidin]- 1' -yl]carbonyl] -4-methyl-benzenesulfonamide; and such compounds are modulators of chemokine (especially CCR3) activity and are especially useful for treating asthma and/or rhinitis.

L'invention concerne des formes anhydrides et hydratées d'un sel de sodium de N-[4-(3, 4-dichlorophénoxy)[1,4'-bipipéridine]-1'-yl]carbonyl]-4-méthyl-benzènesulfonamide et les formes cristallines de N-[[4-(3,4-dichlorophéoxy)[1,4'-bipipéridine-1 -yl]carbonyl]-4-méthyle-benzènesulfonamide; et de tels composés qui sont des modulateurs de l'activité de la chimiokine (spécialement CCR3) et se prêtant particulièrement au traitement de l'asthme et/ou de la rhinite.

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