Preparation of phenoxy-substituted esters and intermediates...

C - Chemistry – Metallurgy – 07 – C

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

260/492, 260/464

C07C 69/16 (2006.01) C07C 69/63 (2006.01) C07C 309/63 (2006.01)

Patent

CA 1305169

- 13 - O.Z. 0050/38855 Abstract of the Disclosure: Compounds of the formula I Image I where R1 is Image or Image where A is C1-C4 alkyl, phenyl or C7-C12-aralkyl and l is 0 or 1, R2 is C1-C4-alkyl, n is 0, 1, 2 or 3, m is 1, 2 or 3 and Y is hydrogen, fluorine, chlorine, brom- ine, C1-C3-alkyl, C1-C3-alkoxy, trifluoromethyl, phenyl or phenoxy, and, when m is greater than 1, the individual atoms or groups Y are identical or different, are pre- pared by a process in which, in a first stage, a diester of the formula II Image II is hydrolyzed with one equivalent of an aqueous alkali metal hydroxide to give the alcohol of the formula IIIa Image IIIa, in a second stage this alcohol is converted with a halo- genating agent or a sulfonyl chloride or bromide into a compound of the formula IIIb Image IIIb where X is a nucleophilically displaceable leaving group, such as chlorine, bromine, mesyl or tosyl, and then, in a third stage, the compound IIIb is reacted with a pheno- late of the formula IV Image IV - 14 - O.Z. 0050/38855 where Y and m have the abovementioned meanings, in the presence of an aprotic solvent to give compound I. Fur- thermore, diesters of the formula II and a process for their preparation are provided, the said diesters being prepared by reacting a lactone of the formula V Image v with a Grignard compound VI R1MgZ VI where 2 is chlorine or bromine, in a nonpolar organic solvent, from 2 to 3 moles of the Grignard compound being used per mole of lactone, and the reaction mixture then being treated with from 2 to 3 moles of anhydride VII Image VII per mole of lactone.

554124

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Preparation of phenoxy-substituted esters and intermediates... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Preparation of phenoxy-substituted esters and intermediates..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation of phenoxy-substituted esters and intermediates... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1187363

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.