Preparation of phosphatase inhibitors

Details Preparation of phosphatase inhibitors Preparation of phosphatase inhibitors

C - Chemistry, Metallurgy

07

C

C07C 311/19 (2006.01) A61K 31/165 (2006.01) A61K 31/166 (2006.01) A61P 7/12 (2006.01) A61P 35/00 (2006.01) C07C 237/22 (2006.01) C07C 311/13 (2006.01) C07C 311/29 (2006.01) C07D 209/14 (2006.01) C07D 209/16 (2006.01) C07D 213/40 (2006.01) C07D 257/04 (2006.01) C07D 307/52 (2006.01)

Patent

CA 2416220

Disclosed are compounds of the Formula (I), and pharmaceutically acceptable salts and prodrugs thereof, wherein A, B, R1, R2, R3, R4 and R5 are as defined in the specification. Such compounds are tyrosine phosphatase inhibitors and useful in the treatment or prevention of Type II Diabetes Mellitus. Also encompassed by the invention are formulations comprising the noted compounds, processes for preparing such compounds, a method for treating or preventing Type II Diabetes Mellitus.

L'invention concerne des composés représentés par la formule (I), des sels et des promédicaments de ceux-ci acceptables du point de vue pharmaceutique. Dans cette formule (I), A, B, R?1¿, R?2¿, R?3¿, R?4¿ et R?5¿ sont tels que définis dans la description. De tels composés sont des inhibiteurs de la tyrosine phosphatase et sont utiles dans le traitement ou la prévention du diabète sucré de type II. L'invention concerne également des préparations contenant lesdits composés, des procédés de préparation de tels composés, ainsi qu'un procédé de traitement ou de prévention du diabète sucré de type II.

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