Preparation of phthalanes

C - Chemistry – Metallurgy – 07 – D

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C07D 307/87 (2006.01)

Patent

CA 2442613

Citalopram and other phthalanes are made by reacting a salt of a compound of formula (II) where R1 is halogen and R2 is halogen, trifluoromethyl, cyano or R-CO- where R is a C1-4 alky1 group, with cuprous cyanide.

L'invention concerne le citalopram et d'autres phtalanes obtenus par la réaction d'un sel d'un composé de la formule (II), dans laquelle R?1¿ est halogène et R?2¿ est halogène, trifluorométhyle, cyano ou R-CO-, R représentant un groupe C¿1-4? alkyle, avec du cyanure cuivreux.

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