Preparation of platinum(ii) complexes

C - Chemistry – Metallurgy – 07 – F

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C07F 15/00 (2006.01)

Patent

CA 2576834

This invention relates to a method for the preparation of a platinum(II) complex containing a neutral bidentate ligand, such as oxaliplatin. The method includes the step of reacting a halogenoplatinum complex containing a neutral bidentate ligand with an oxalate salt in a solvent, wherein more than 1 g/L of the oxalate salt is soluble in the solvent. The invention also relates to new platinum(II) complexes.

L'invention concerne un procédé de préparation d'un complexe de platine (II) contenant un ligand bidentate neutre tel que l'oxaliplatine. Ce procédé comprend l'étape consistant à faire réagir un complexe d'halogénoplatine contenant un ligand bidentate neutre avec un sel d'oxalate dans un solvant, plus d'1 g/L de ce sel d'oxalate étant soluble dans le solvant. L'invention concerne également de nouveaux complexes de platine (II).

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