C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 15/00 (2006.01)
Patent
CA 2640621
This invention relates a method for the preparation of platinum(II) oxalato complexes from their dihalogenoplatinum(II) precursors having either neutral monodentate or bidentate non-leaving co-ligands. Of particular interest is oxaliplatin. The method includes the step of reacting a halogenoplatinum(II) complex containing a neutral monodentate or bidentate ligand with an oxalate in a non-aqueous solvent or a mixed solvent system. The mixed solvent system is solvent mixture containing a non-aqueous solvent and water. According to the present invention, the non-aqueous solvent is an alcohol.
La présente invention concerne un procédé de préparation de complexes oxalato-platine (II) à partir de leurs précurseurs dihalogénoplatine (II) possédant des co-ligands non partants monodentates ou bidentates neutres. L~oxaliplatine est d~un intérêt particulier. Le procédé comprend l'étape consistant à faire réagir un complexe halogénoplatine (II) contenant un ligand monodentate ou bidentate neutre avec un oxalate dans un solvant non aqueux ou un système de solvants mélangés. Le système de solvants mélangés est un mélange de solvants contenant un solvant non aqueux et de l'eau. Selon la présente invention, le solvant non aqueux est un alcool.
Borden Ladner Gervais Llp
Platco Technologies (proprietary) Limited
LandOfFree
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