Preparation of quinoline-substituted carbonate and carbamate...

Details Preparation of quinoline-substituted carbonate and carbamate... Preparation of quinoline-substituted carbonate and carbamate...

C - Chemistry, Metallurgy

07

D

C07D 215/14 (2006.01)

Patent

CA 2368768

The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal- catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or a substrate that can be reduced to obtain the same.

L'invention concerne un procédé permettant la préparation de composés de carbonate et de carbamate à substitution quinoline, qui sont des intermédiaires importants de la synthèse d'antibiotiques macrolides substitués en 6-O-. Ce procédé fait appel à des réactions de couplage à catalyseur métallique permettant d'obtenir un carbonate ou un carbamate de formule (I) ou (II) ou un substrat donnant un tel composant après réduction.

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