C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 215/60 (2006.01) A61K 31/135 (2006.01) A61P 9/00 (2006.01) A61P 11/06 (2006.01) C07C 217/60 (2006.01)
Patent
CA 2660707
This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding .beta.2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.
La présente invention concerne la découverte d'analogues de (R,R)- et (R,S)-fénotérol qui sont hautement efficaces pour se lier aux récepteurs .beta.2-adrénergiques. L'invention concerne également des structures chimiques exemplaires de ces analogues, des compositions pharmaceutiques incluant le (R,R)-fénotérol et les analogues de fénotérol décrits, ainsi que des procédés d'utilisation de tels composés et de telles compositions pour le traitement de troubles cardiaques tels que l'insuffisance cardiaque congestive et des troubles pulmonaires tels que l'asthme ou la maladie pulmonaire obstructive chronique.
Abernethy Darrell R.
Beigi Farideh M.
Chakir Khalid
Wainer Irving W.
Xiao Rui Ping
Smart & Biggar
The Government Of The United States Of America As Represented By
LandOfFree
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