Preparation of red blood cells with a modified level of...

Details Preparation of red blood cells with a modified level of... Preparation of red blood cells with a modified level of...

G - Physics

01

N

G01N 33/80 (2006.01) C12S 3/22 (2006.01) G01N 33/96 (2006.01) C12N 5/078 (2010.01)

Patent

CA 2516123

A method for the preparation of red blood cells expressing reduced levels of blood group antigens using at least one immunodominant sugar modifying enzyme, for example alpha-N- acetylgalactosaminidase or alpha-galactosidase. The red blood cells produced preferably express a level of antigen substantially equivalent to the clinically significant threshold for the antigen. Red blood cells produced according to said method are used for the quality control of blood typing reagents and the calibration of testing systems to give accurate and standardized determinations of blood group types.

L'invention porte sur un procédé de préparation des globules rouges exprimant des taux réduits d'antigènes de groupes sanguins qui consiste à utiliser au moins une enzyme modifiant le sucre immunodominant, telle que alpha-N-acétylgalactosaminidase ou alpha-galactosidase. Les globules rouges produits expriment de préférence un taux d'antigènes sensiblement équivalent au seuil significatif du point de vue clinique de l'antigène. Les globules rouges produits selon ce procédé sont utilisés pour le contrôle qualité des réactifs de détermination des groupes sanguins et le calibrage des systèmes de test afin d'obtenir des déterminations précises et standardisées des groupes sanguins.

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