Preparation of romidepsin

Details Preparation of romidepsin Preparation of romidepsin

C - Chemistry, Metallurgy

07

K

C07K 5/10 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2674309

The invention provides an improved process for preparing romidepsin. The process involves producing, purifying, or storing romidepsin under conditions that prevent the formation of undesired adducts. Purifying romidepsin at an apparent pH lower than approximately 6.0 (e.g., between an apparent pH of 4.0 and 6.0) has been discovered to prevent the reduction of the disulfide bond of romidepsin and the subsequent formation of dimerized, oligomerized, or polymerized adducts. The invention also provides compositions of monomeric romidepsin free of dimerized, oligomerized, or polymerized adducts.

L'invention concerne un meilleur procédé de préparation de la romidepsine. Le procédé implique la production, la purification ou le stockage de la romidepsine dans des conditions qui empêchent la formation de produits d'addition non souhaités. La purification de la romidepsine à un pH apparent inférieur à approximativement 6,0 (par exemple, entre un pH apparent de 4,0 et 6,0) s'est avérée empêcher la réduction de la liaison disulfure de la romidepsine et la formation ultérieure de produits d'addition dimérisés, oligomérisés ou polymérisés. L'invention concerne également des compositions de romidepsine monomère dépourvues de produits d'addition dimérisés, oligomérisés ou polymérisés.

Affiliated with

Also associated with

Rating

Preparation of romidepsin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Preparation of romidepsin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation of romidepsin will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1893877