Preparation of (s)-4-fluoromethyl-dihydro-furan-2-one

Details Preparation of (s)-4-fluoromethyl-dihydro-furan-2-one Preparation of (s)-4-fluoromethyl-dihydro-furan-2-one

C - Chemistry, Metallurgy

07

D

C07D 307/32 (2006.01) C07D 307/38 (2006.01)

Patent

CA 2607927

This invention relates to a process of the preparation of the novel intermediate (S)-4-fluoromethyl-dihydro-furan-2-one of the formula (I) and with its use for the manufacture of pyrido[2,1-a] isoquinoline derivatives of the formula (II) which are useful for the treatment and / or prophylaxis of diseases which are associated with DPP IV.

Procédé de préparation du nouvel intermédiaire (S)-4-fluorométhyl-dihydro-furan-2-one de formule (I) et utilisation dudit intermédiaire pour la production de dérivés de pyrido[2,1-a]isoquinoline de formule (II) qui sont utiles pour le traitement et / ou la prophylaxie de maladies associées à DPP IV.

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