Preparation of sodium-hydrogen exchanger type-1 inhibitors

Details Preparation of sodium-hydrogen exchanger type-1 inhibitors Preparation of sodium-hydrogen exchanger type-1 inhibitors

C - Chemistry, Metallurgy

07

C

C07C 243/22 (2006.01) A61K 31/415 (2006.01) A61K 31/4709 (2006.01) A61P 9/00 (2006.01) C07D 215/38 (2006.01) C07D 231/14 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2430061

This invention relates to methods of preparing sodium-hydrogen exchanger type 1 (NHE-1) inhibitors of formula (I') intermediates of the NHE-1 inhibitors and a new almost colorless form of the NHE-1 inhibitor N-(5-cyclopropyl-1-quinolin- 5-yl-1H-pyrazole-4-carbonyl)-guanidine.

L'invention concerne des procédés de préparation d'inhibiteurs de type 1 d'échangeur sodium-hydrogène (NHE-1) de formule (I'), des intermédiaires des inhibiteurs NHE-1 et une nouvelle forme presque sans couleurs de l'inhibiteur NHE-1 N-(5-cyclopropyl-1-quinolin-5-yl-1H-pyrazole-4-carbonyl)-guanidine.

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