Preparation of submicron sized particles with polymorph...

Details Preparation of submicron sized particles with polymorph... Preparation of submicron sized particles with polymorph...

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/127 (2006.01) A61K 9/14 (2006.01) A61K 31/495 (2006.01)

Patent

CA 2498043

The present invention provides a method of preparing particles with polymorph and size control of a pharmaceutical compound, the method including the steps of: (1) providing pharmaceutical compound in a first phase; (2) seeding the compound; (3) causing a phase change in the pharmaceutical compound to a second phase of a desired polymorphic form; and (4) wherein the mean particle size of the particles is less than 7~m. The present invention further provides a polymorphic form of itraconazole.

La présente invention concerne un procédé de préparation de particules avec régulation polymorphique et régulation de taille d'un composé pharmaceutique, ce procédé consistant (1) à utiliser un composé pharmaceutique présentant une première phase, (2) à réaliser la germination de ce composé, (3) à provoquer un changement de phase du composé pharmaceutique de manière à obtenir une seconde phase d'une forme polymorphique souhaitée, et (4) à réguler la taille moyenne des particules de façon qu'elle soit inférieure à 7 µm. La présente invention concerne également une forme polymorphique d'itraconazole.

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