C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/08 (2006.01)
Patent
CA 2527337
The present invention relates to a new process for the preparation of substituted quinoxalines (I) by cyclization of the corresponding dianiline with 2,3 dihydroxy-1,4-dioxane. In a preferred embodiment, the invention provides a process for the preparation of compounds having the formula III wherein Q is a nitrogen protecting group. Compounds of formula III and their derivatives are precursors to certain aryl fused azapolycyclic compounds which exhibit activity as agents for the treatment of neurological and psychological disorders.
La présente invention se rapporte à un nouveau procédé de préparation de quinoxalines substituées (I) par cyclisation de la dianiline correspondante avec du 2,3 dihydroxy-1,4-dioxane. Selon un mode de réalisation préféré, l'invention concerne un procédé de préparation de composés selon la formule III, dans laquelle Q représente un groupe protecteur d'azote. Les composés selon la formule III et leurs dérivés sont des précurseurs de certains composés azapolycycliques condensés avec aryle, agissant comme agents dans le traitement d'affections neurologiques et psychologiques.
Rainville Joseph Philip
Taber Geraldine Patricia
Pfizer Products Inc.
Sim & Mcburney
LandOfFree
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