Preparation of therapeutic agents

Details Preparation of therapeutic agents Preparation of therapeutic agents

C - Chemistry, Metallurgy

07

C

260/507, 260/531

C07C 59/68 (2006.01) C07C 57/58 (2006.01) C07C 59/56 (2006.01) C07C 59/64 (2006.01)

Patent

CA 1105942

ABSTRACT Disclosed is a process for increasing the proportion of a desired enantiomer of a 2-arylpropionic acid which comprises heating at a temperature of at least 80°C a mixture comprising an inert liquid organic diluent and a salt of the 2-arylpropionic acid with an enantiomer of a chiral organic nitrogenous base, the base and the diluent being such that the salt of the racemic acid has a solubility of 0.1 to 10% w/v in the diluent at the operating temperature and in whidh process a proportion of the salt is undissolved in the diluent, whereby a proportion of one optical isomer of the acid component of the salt is converted into its enantiomer, and collecting the salt of which the acid component has an increased proportion of that enantiomer. -1-

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