Preparation of thioamides of .beta.-lactam antibiotics

Details Preparation of thioamides of .beta.-lactam antibiotics Preparation of thioamides of .beta.-lactam antibiotics

C - Chemistry, Metallurgy

07

D

260/118.5

C07D 499/04 (2006.01) C07D 499/00 (2006.01) C07D 499/58 (2006.01) C07D 499/78 (2006.01)

Patent

CA 1036593

A B S T R A C T The invention relates to compounds of the formula: Image wherein R stands for benzyl, phenoxymethyl, 4-amino-4-carboxy-1-butyl, R3O-, R3S-, R3R4N- wherein R3 is loweralkyl, aryl or arylloweralkyl, R4 is hydrogen or R3, and R2 is hydrogen or methoxy, and R1 is hydrogen or a cleavable radical such as -CH2OCH3, loweralkyl, 2,2,2-trichloroethyl, benzyl, p-nitrobenzyl, benzhydryl, phenacyl or trimethyl- silyl. The novel compounds are useful intermediates in the preparation of known penicillin and cephalosporin derivatives.

209225

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