Preparation of trifluorobenzoic acids

Details Preparation of trifluorobenzoic acids Preparation of trifluorobenzoic acids

C - Chemistry, Metallurgy

07

C

C07C 63/70 (2006.01) C07C 51/08 (2006.01) C07C 51/38 (2006.01) C07C 63/72 (2006.01) C07C 65/21 (2006.01) C07C 255/51 (2006.01)

Patent

CA 2288485

The present invention relates to a process for preparing trifluorobenzoic acids of the formula (see above formula I) in which R is a straight-chain or branched alkyl radical having 1 to 6 C- atoms, an unsubstituted phenyl radical, a substituted phenyl radical which contains one or two alkyl or alkoxy groups having in each case 1 to 4 C atoms, or an araliphatic radical having 7 to 12 C atoms, which comprises reacting a compound of the formula (see formula II) in which R1 and R2 are identical or different and are -CN, -COOR3, where R3 is H, Li, Na, K, MgCL, MgBr, Mgl, 1/2Mg, 1/2Ca or an alkyl radical having 1 to 6 C atoms, or -CONR4R5, where R4 and R5 are identical or different and are an alkyl radical having 1 to 6 C atoms, with at least one organometallic compound of the formula CuR, CuLiR2, MgXR, ZnR2, LiR, ALX2R, ALXR2, ALR3 or AL2CL3R3, where R is as defined in formula (1) and X is Cl, Br or I, in the presence of an inert solvent at from - 80 to +150°C, treating the reaction product in the presence of water in the absence or presence of an acid at from 0 to 250°C and decarboxylating the resulting trifluoroisophthalic acid of the formula Image at from 80 to 280°C.

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