Preparation of virus-free immunoglobulins

Details Preparation of virus-free immunoglobulins Preparation of virus-free immunoglobulins

C - Chemistry, Metallurgy

12

N

C12N 7/06 (2006.01) A61K 39/395 (2006.01) C07K 16/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2063303

Antibodies, including monoclonal antibodies (Mabs) can be made substantially free of infectious viruses by storing them in a liquid state at conditions of pH, temperature and time sufficient to inactive substantially all infectious viruses. Preferred inactivation methods involve use of a pH equal to or less than about 4.0 at a temperature of at least about 5°C for at least about 16 hours.

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