Preparation of warfarin sodium from warfarin acid

Details Preparation of warfarin sodium from warfarin acid Preparation of warfarin sodium from warfarin acid

C - Chemistry, Metallurgy

07

D

C07D 311/46 (2006.01)

Patent

CA 2438407

The invention provides a method for the direct preparation of pure warfarin sodium from warfarin acid. The reaction is conducted in a polar organic solvent, preferably ethanol, using a volatilizable base, preferably sodium bicarbonate or sodium carbonate, at low temperature. Drying the final product is accomplished at low temperature to avoid decomposition of the final warfarin sodium product.

L'invention concerne un procédé destiné à la préparation directe de warfarine sodique pure. La réaction est effectuée dans un solvant organique polaire, de préférence de l'éthanol, en utilisant une base volatilisable, de préférence du bicarbonate de sodium ou du carbonate de sodium, à basse température. Le séchage du produit final est accompli à basse température afin d'éviter la décomposition du produit final de warfarine sodique.

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