Preparation process for an aqueous pharmaceutical solution...

Details Preparation process for an aqueous pharmaceutical solution... Preparation process for an aqueous pharmaceutical solution...

A - Human Necessities

61

K

167/163

A61K 9/08 (2006.01) A61K 47/00 (2006.01)

Patent

CA 1292944

Company named: Laboratoires CHAUVIN-BLACHE Inventors: - MAURIN Florence - COQUELET Claude - TOURNOUX Alain Preparation process for an aqueous pharmaceutical solution of an active principle constituted by an organic acid ABSTRACT The subject of the invention is a preparation process for an aqueous pharmaceutical solution of an active principle constituted by an organic acid, characterized in that: a) the organic acid is dissolved in a first aqueous solution contain- ing a sufficient quantity of at least a fraction of the basic part of a buffer mixture b) this solution is lyophilized in order to obtain a product in a dry state and c) at the time of use the product in a dry state is dissolved in a second aqueous solution containing the remainder of the buffer mixture, this remainder being such that the pH of the resulting solution is of a physiologically acceptable value. Fig. None

535901

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