Preparation process for trifluorothymidine derivatives

Details Preparation process for trifluorothymidine derivatives Preparation process for trifluorothymidine derivatives

C - Chemistry, Metallurgy

07

H

C07H 19/073 (2006.01) C07H 19/06 (2006.01)

Patent

CA 2354888

5-trifluoromethyl-2,4-bis(trimethylsilyloxy)pyrimidi ne is reacted with a 2-deoxy-.alpha.-D-erythro-pentofuranosyl chloride derivative reacted in the absence or presence of a small amount of solvent to give a .beta.-form of 1-(2'-deoxy-.beta.-D-erythro-pentofuranosyl)-5-trifluoromethyl uracil derivative with a high selectivity.

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