Preparation process of .alpha.-l-aspartyl-l-phenylalanine...

Details Preparation process of .alpha.-l-aspartyl-l-phenylalanine... Preparation process of .alpha.-l-aspartyl-l-phenylalanine...

C - Chemistry, Metallurgy

07

K

530/5.06

C07K 5/06 (2006.01) C07K 5/075 (2006.01)

Patent

CA 1286845

ABSTRACT Disclosed herein is a process for preparing a-L-aspartyl-L-phenylalanine methyl ester or its hydrochloride from 5-benzyl-3,6-dioxo-2-piperazine acetic acid or its methyl ester, prepared without using L-penylalanine methyl ester which involves problems in its stability, as a raw material. Specifically, the process comprises: bringing 5-benzyl-3,6-dioxo-2- piperazine acetic acid in the presence of methanol or 5-benzyl-3,6-dioxo-2-piperazine acetic acid methyl ester in the presence or absence of methanol into contact with hydrochloric acid; isolating the thereby deposited a-L-aspartyl-L-phenylalanine methyl ester hydrochloride; and neutralizing said hydrochloride with an alkali as required. Preparation processes of 5- benzyl-3,6-dioxo-2-piperazine acetic acid or its methyl ester are also disclosed.

504693

Affiliated with

Also associated with

Rating

Preparation process of .alpha.-l-aspartyl-l-phenylalanine... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Preparation process of .alpha.-l-aspartyl-l-phenylalanine..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation process of .alpha.-l-aspartyl-l-phenylalanine... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1304539