Preparation process of -l-aspartyl-l-phenylalanine methyl ester

Details Preparation process of -l-aspartyl-l-phenylalanine methyl ester Preparation process of -l-aspartyl-l-phenylalanine methyl ester

C - Chemistry, Metallurgy

07

K

530/5.06

C07K 5/06 (2006.01) C07K 1/12 (2006.01) C07K 5/075 (2006.01)

Patent

CA 1277098

- 36 - Abstract of the Disclosure: This invention relates to an improved process for preparing .alpha.-L-aspartyl-L-phenylalanine methyl ester. More specifically, it relates to a process for preparing .alpha.-L-aspartyl-L-phenylalanine methyl ester which comprises treating, as a raw material, N-formyl-.alpha.-L-aspartyl-L-phenylalanine in methanol in the presence of an acid to form .alpha.-L- aspartyl-L-phenylalanine dimethyl ester, hydrolyzing the .alpha.-L-aspartyl-L-phenylalanine dimethyl ester by bringing it into contact with hydrochloric acid in the presence of methanol as desired, separating the thereby-precipitated .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride and neutralizing the hydrochloride. Further, this invention also proviaes a process for preparing .alpha.-L-aspartyl-L-phenylalanine methyl ester capable of using, as a raw material, N-formyl-.alpha.-L-aspartyl-L-phenylalanine which contains N-formyl-.beta.-L-aspartyl-L-phenylalanine in an amount of 30% by weight or less.

498219

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