G - Physics – 01 – N
Patent
G - Physics
01
N
167/37
G01N 33/571 (2006.01) G01N 33/569 (2006.01)
Patent
CA 1230551
ABSTRACT OF THE DISCLOSURE A preparation is provided herein which may be used for diagnostic purposes for the detection of chlamydial infections. The preparation comprises a Re-lipopolysaccharide complexed to a carrier molecule to enhance immunological response isolated from the Re-mutants of Gram negative bacteria or an anti body to a Re-lipopolysaccharide complexed to a carrier molecule to enhance immunological response, the anti-Re-lipopolysaccharide complex antibody being produced by immunizing animals with Re-lipopolysaccharide complexed to a carrier molecule to enhance immunological response. The anti-Re-lipopoly- saccharide complex antibody is capable of cross-reacting with chlamydial group-specific antigens. Advantageously, the Re-mutants of Gram negative bacteria are Salmonella minnes ta mR595, deposit No. SH 320, Public Health Institute, Helsinki, Finland, Salmonella typhimurium Re, deposit No. SL 1102, Public Health Institute, Helsinki, Finland, Escherichia coli D21f2, deposit No. EH237, Public Health Institute, Helsinki, Finland or Proteus mirabilis R45, deposit No. EH 193, Public Health Institute, Helsinki, Finland. The lipopolysaccharide preparation is used in the production of group-specific antibodies to chlamydial for diagnostic purposes or for the demonstration of antibodies to chlamydial group antigne in specimens. Thus, the product can be used for the demonstration of chlamydial infections, for example in various serological and immunolgical methods, e.g. the counterimmunoelectrophoresis method, passive hemagglutination method, and the HIG, EIA, FIA, RIA and latex agglutinization methods.
431720
Leinonen Maija K.
Makela Pirjo H.
Nurminen-Kalliokoski Marjatta H.
Saikku Pekka A.i.
Borden Ladner Gervais Llp
Leinonen Maija K.
Makela Pirjo H.
Nurminen-Kalliokoski Marjatta H.
Saikku Pekka A.i.
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