Preparative process for 3-amino-2-thioxo-oxazolidin-4-ones

Details Preparative process for 3-amino-2-thioxo-oxazolidin-4-ones Preparative process for 3-amino-2-thioxo-oxazolidin-4-ones

C - Chemistry, Metallurgy

07

D

260/242, 260/304

C07D 263/46 (2006.01) C07D 263/52 (2006.01) C07D 413/04 (2006.01) C07D 498/10 (2006.01)

Patent

CA 2015098

TITLE PREPARATIVE PROCESS FOR 3-AMINO-2-THIOXO-OXAZOLIDIN-4-ONES ABSTRACT OF THE DISCLOSURE A new process for the preparation of 3-amino- 2-thioxo-oxazolidin-4-ones comprising sequential reaction, in an organic medium, of a 2-hydroxy- carboxylic acid ester with a base, with carbon disulfide, with an acylating agent, and with a substituted hydrazine. The products are useful as antifungal agents. An exemplary compound prepared by the process is 5-methyl-5-phenyl-3-phenylamino-2- thioxo-oxazolidin-4-one.

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