C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
260/472.3, 260/5
C07C 53/132 (2006.01) C07C 69/76 (2006.01)
Patent
CA 1164469
4057 ABSTRACT In preparing arylalkanoic acids, e.g., ibuprofen or naproxen, via the conversion of the selected .alpha.-haloketal derivative of a 1-haloethyl aryl ketone to the haloalkyl ester of the arylalkanoic acid using a zinc salt catalyst the improvement comprising reacting a ring-substi- tuted 6-membered ring ketal of the selected 1-haloethyl C6-C12-aryl ketone with a soluble zinc carboxylate salt to form the corresponding 3-haloalkyl arylalkanoic acid ester. The ester is converted to the alkali metal salt of the acid with base in an aqueous/water insoluble organic liquid mixture and the crude salt is converted to the corre- sponding acid in an aqueous/water insoluble solvent mixture for the acid, the organic solution of the acid is washed with a pH 7.0 to 8.0 buffer solution, and the arylalkanoic acid product is separated from the mother liquor which mother liquor is recycled to the alkali metal arylalkanoate salt forming step of the process to accumulate and recover the arylalkanoic acid values which remained in the mother liquor.
439426
Amin Sanjay I.
Walker Jerry A.
Macrae & Co.
Upjohn Company (the)
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