Preparing porous hydrogel products

Details Preparing porous hydrogel products Preparing porous hydrogel products

C - Chemistry, Metallurgy

08

J

C08J 9/36 (2006.01) A61L 27/20 (2006.01) A61L 27/52 (2006.01) A61L 27/56 (2006.01) A61L 31/04 (2006.01) A61L 31/14 (2006.01) C08J 9/08 (2006.01) C08J 9/30 (2006.01) C12N 5/00 (2006.01)

Patent

CA 2364570

This invention is directed to a new approach to form porous hydrogel materials by first creating gas pockets in the gel and then removing this gas. The removal of the gas creates a porous material, and the initial incorporation of sufficient gas allows one to create a material with an open, interconnected pore structure. Advantageous features of the resulting materials, in addition to their interconnected pore structure, may include that the pore structure is maintained over extended time periods and that the gels maintain a high mechanical integrity that allows seeding with cells and implantation without destruction or compression of the material.

L'invention concerne une nouvelle approche de production de matières à base d'hydrogel poreux. Premièrement, on crée, dans le gel, des poches de gaz d'où l'on retire ensuite le gaz, ce qui a pour effet de créer une matière poreuse alors que l'incorporation initiale d'une quantité suffisante de gaz permet d'obtenir une matière présentant une structure ouverte interconnectée. Outre sa structure poreuse interconnectée, la matière ainsi obtenue présente plusieurs avantages. Notamment, cette structure peut conserver sa porosité pendant de longues périodes alors que le gel conserve une intégrité mécanique élevée qui permet de loger des cellules et de pratiquer des implantations sans que cela n'entraîne la destruction ou la compression de ladite matière.

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