C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 7/04 (2006.01) C07K 7/22 (2006.01) C07K 16/18 (2006.01) C12N 15/85 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2271714
The present invention provides a new mammalian preprotachykinin-c gene (PPT-C) which encodes a precursor protein for a new tachykinin peptide called Substance Z. Substance Z has vasodilative effects and is expressed in hematopoietic tissues. The identification and isolation of this peptide provides the basis for development of therapeutic strategies for immune disorders in which Substance Z is involved as well as for development of antibodies and antagonists for the peptide.
La présente invention concerne un nouveau gène de la préprotachykinine-c humaine (PPT-C) codant une protéine précurseur d'un nouveau peptide tachykinine appelé "substance Z". Cette substance possède des effets vasodilatateurs et elle est exprimée dans des tissus hématopoïétiques. L'identification et l'isolement de ce peptide ont servi de base au développement de stratégies thérapeutiques de lutte contre des désordres immuns dans lesquelles la substance Z est impliquée, ainsi qu'à la mise au point d'anticorps et d'antagonistes de ce peptide.
Paige Christopher J.
Wu Gillian E.
Zhang Yu
Sim & Mcburney
The Wellesley Hospital Foundation
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