Preservative system for emulsion-based therapeutic topical...

A - Human Necessities – 61 – K

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A61K 31/7048 (2006.01) A61K 9/107 (2006.01) A61K 47/14 (2006.01) A61P 33/14 (2006.01)

Patent

CA 2741886

A topical formulation that inhibits the growth of microorganisms comprises an effective amount of an insecticide dissolved in an oil phase comprising a water-miscible or water-soluble surface active agent, a suspending agent, and a non-ionic surfactant, and an aqueous phase comprising one or more preservatives, where the aqueous phase is buffered to a specific pH. The overall antimicrobial efficacy in an emulsion formulation can be enhanced by buffering the aqueous phase of the emulsion to a pH at which the preservative system inhibits growth for a wider variety of microorganism types in the formulation relative to the equivalent formulation in which the aqueous phase is not buffered.

L'invention porte sur une formulation topique qui inhibe la croissance de microorganismes, et qui comprend une quantité efficace d'un insecticide dissous dans une phase huileuse comprenant un agent tensioactif miscible dans l'eau ou soluble dans l'eau, un agent de suspension et un tensioactif non ionique, et une phase aqueuse comprenant un ou plusieurs conservateurs, la phase aqueuse étant tamponnée à un pH spécifique. L'efficacité antimicrobienne globale dans une formulation d'émulsion peut être renforcée par le tamponnage de la phase aqueuse de l'émulsion à un pH auquel le système de conservation inhibe la croissance pour une plus grande variété de types de microorganisme dans la formulation par rapport à la formulation équivalente dans laquelle la phase aqueuse n'est pas tamponnée.

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