A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/40 (2006.01) A61K 9/00 (2006.01) A61K 47/02 (2006.01) A61K 47/18 (2006.01) A61K 47/24 (2006.01) A61K 47/12 (2006.01)
Patent
CA 2232435
Disclosed are preservative systems useful in aqueous pharmaceutical compositions containing an active agent and a cyclodextrin. The preservative systems comprise boric acid and one or more compounds selected from the group consisting of C16 benzalkonium halide compounds, polymeric quaternary ammonium compounds, and quaternary ammonium alkylene glycol phospholipid derivatives of structure (I), where a + b = 3; R1 is C8-C22 alkyl or alkene; X is NH, O or CH2; R2 is C2-C6 alkyl; each R3 is independently C1-C12 alkyl or alkene; and Y is nothing or C1-C6 alkyl or alkene; and pharmaceutically acceptable salts thereof.
La présente invention concerne des systèmes conservateurs, et certains de leurs sels pharmaceutiquement admis, convenant particulièrement aux compositions pharmaceutiques aqueuses contenant un principe actif et une cyclodextrine. De tels systèmes conservateurs sont constitués d'acide borique et d'un composé au moins appartenant au groupe des composés halogénés du C16 benzalconium, des composés polymères d'ammonium quaternaire et des dérivés phospholipides d'alkylène glycol de l'ammonium quaternaire représentés par la formule générale (I). Dans cette formule générale (I), a + b = 3; R<1> est C8-C22 alkyle ou alcène; X est NH, O ou CH2; R<2> est C2-C6 alkyle; chaque R<3> est indépendamment C1-C6 alkyle ou alcène; et Y n'est rien ou C1-C6 alkyle ou alcène.
Castillo Ernesto J.
Espino Ramon L.
Alcon Laboratories Inc.
Smart & Biggar
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