Pressure-mediated binding of biomolecular complexes

Details Pressure-mediated binding of biomolecular complexes Pressure-mediated binding of biomolecular complexes

G - Physics

01

N

G01N 33/53 (2006.01) B01J 3/00 (2006.01) C07K 1/00 (2006.01) C11B 7/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/543 (2006.01) G01N 33/569 (2006.01) G01N 33/574 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2259318

The invention relates to (1) pressure-mediated dissociation of an analyte complexed with an endogenous binding partner to enable detection of a complex formed from the analyte and an exogenous binding factor, (2) pressure-mediated association of an analyte and an exogenous binding partner to enable more rapid and/or more sensitive detection of an analyte, and (3) pressure-mediated association and dissociation of biomolecular complexes to enable separation of one biomolecule from a complex mixture. Pressure can be used to improve assays by dissociating endogenous analyte complexes and improving assay speed and sensitivity by associating the analyte molecules with exogenously supplied binding partners. Pressure can also be used to improve the separation of compounds from contaminated mixtures.

La présente invention concerne : (1) une dissociation contrôlée par pression d'un anlyte complexé avec un partenaire d'association endogène permettant la détection d'un complexe formé de l'analyte et d'un agent d'association exogène, (2), une association contrôlée par pression d'un anlyte avec un partenaire d'association exogène permettant une détection plus rapide et/ou plus fine d'un anlyte et (3) une association et une dissociation contrôlées par pression de complexes biomoléculaires permettant la séparation d'une biomolécule dans un mélange complexe. On peut utiliser la pression pour perfectionner les techniques en dissociant les complexes endogènes de l'analyte et les vitesses de test en associant les molécules de l'analyte avec des partenaires à association exogène. La pression peut aussi être employée pour améliorer la séparation de composés de mélanges contaminés.

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