A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/00 (2006.01) A61K 31/00 (2006.01) A61K 31/4704 (2006.01) A61K 31/485 (2006.01) A61K 45/06 (2006.01) A61K 47/10 (2006.01)
Patent
CA 2477885
The present invention relates to a pharmaceutical formulation for use in the administration of 2(1H)-quinolinone derivatives long-acting .beta.2-agonists by inhalation. In particular this invention relates to a chemically stable highly efficient TA 2005 HFA solution formulation to be administered by pressurised metered dose inhalers (pMDIs) characterized by a deep lung penetration. The invention also relates to methods for the preparation of said formulation and to its use in respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD).
L'invention concerne une formulation pharmaceutique s'utilisant dans le cadre de l'administration de .beta.2-agonistes à action prolongée de dérivés de 2-(1H)-quinolinone, par inhalation. L'invention concerne en particulier une formulation de solution HFA TA 2005 hautement efficace, chimiquement stable, à administrer par aérosols-doseurs pressurisés (pMDI), qui se caractérise en ce qu'elle pénètre profondément dans les poumons. L'invention concerne en outre des procédés permettant de préparer ladite formulation et son utilisation dans des affections respiratoires telles que l'asthme et la maladie pulmonaire obstructive chronique (MPOC).
Brambilla Gaetano
Church Tanya Kathleen
Davies Rebecca Jaine
Ferraris Alessandra
Ganderton David
Chiesi Farmaceutici S.p.a.
Kirby Eades Gale Baker
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