Presynaptic protein p120

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12P 21/02 (2006.01) C12Q 1/02 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2478016

The present invention enabled the detection and quantification of p120 protein, which is localized to synapses and tightly bound to the cytomatrix, and of the mRNA encoding the p120 protein. Furthermore, it was revealed that p120 functions as a protein scaffold for localizing RIM1 to synapses, contributing as a molecular basis for active zone formation.

Selon l'invention, il est possible de détecter et de quantifier l'ARNm codant une protéine p120, laquelle est située dans les synapses et fortement liée au squelette cellulaire, ainsi que la protéine p120. En outre, il est établi clairement que la protéine p120 sert de structure en vue de localiser un RIM1 dans les synapses et contribue en tant que base moléculaire à la formation de la zone active.

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